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The initial divergence of the two sequences is roughly exponential, each pair of terms being different by an amount greater than that of the preceding pair by a roughly constant factor.
In addition, the initial divergence within the NA OPXV appears to have occurred much earlier than the apparently more recent and/or rapid radiation of known Old World OPXV.
Our results indicate that complete loss of UGT1A6 mediated glucuronosyltransferase activity occurred via pseudogene fixation following divergence of the Felidae from all other feliform families approximately 37 MYA, and prior to the initial divergence of the extant felid lineages 11 MYA.
(XI) 24.5 Ma MDD = 5.4) for the initial divergence of asterophryine genera (excluding Gastrophrynoides).
(II) 84.8 Ma MDD = 8.4) for the initial divergence of extant microhylid subfamilies (i.e., split of Phrynomerinae from other microhylids).
The initial divergence of the T. semitaeniatus species group took place in the Late Miocene Pliocene transition.
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However, the chronology of the initial divergences in southern Africa is not clear, because alternative scenarios are statistically not rejected.
The initial divergences within the Aquifoliales were inferred to have occurred within Australasia (e.g. w i = 0.11, evidence ratio = 2.49 for crown Aquifoliales).
The initial divergences within Clade 2 occur before the beginning of the MSC, with confidence intervals indicating a possibility that diversification could have begun during the MSC.
The initial divergences within Asterales were also confidently reconstructed as being within the Australasian region (e.g. w i = 0.83 for crown Asterales; Figure 2).
In conclusion, this study showed that despite the initial divergences in celecoxib use between Queensland and Australia, the use of ns-NSAIDs, COX-2 inhibitors and paracetamol overall, in concession beneficiaries, was comparable in Australia and Queensland.
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