Sentence examples for the initial compound from inspiring English sources

The in vitro aldose reductase inhibitory activity of the prepared 1 7 compounds were estimated and compared with that of the initial compound (I).

This approach led us to design chemical modifications of the central pyrazole, which solved the poor kinase selectivity seen as a strong liability for the initial compound 1.

Within this series of compounds, 4m is the most potent GPa inhibitor (IC50 = 2.68 μM), which is nearly 100 times more potent than the initial compound 1.

In the case of electron irradiation, the precipitating bcc phase exhibits preferential crystallographic orientation with respect to the initial compound crystal for irradiation temperatures above 200 K.

Paul Herrling, chairman of the Novartis Institute for Tropical Diseases in Singapore, said this was not a case of evergreening because the initial compound was never marketed or intended for market.

Pure and single phase materials that are isostructural to the initial compound will be produced.

The nature of the initial compounds clearly affects the products of the different stages of carbonization and the first steps of graphitization.

We note that the structure in Fig. 7c have a slightly better predicted activity (pACT = 9.015) than the initial compounds used in the training set, while the structure in Fig. 7d have the same predicted activity than gentamicin (pACT = 8.867).

Some of the initial compounds were purified in an HPLC semi-preparative Waters 600 with Dual absorbance detector Waters 2487 (Waters, Milford, USA), with a Symmetry C18 column (100×30 mm×5 µm, 100 Å, Waters), which also incorporates a Waters 2700 automatic injector and a Waters Fraction Collector II.

Pathways for degradation of aromatic compounds typically begin with specialized enzymes that convert the initial compounds to catechol or hydroquinone intermediates that are then cleaved by intradiol or extradiol dioxygenases.

At the same time, hydrazide groups react with aldehydes in a low acidic medium, where the equilibrium of the aldehyde-and-amine reaction is significantly shifted to the initial compounds.