The inheritance of cellular material between parent and daughter cells during mitosis is highly influential in defining the properties of the cell and therefore the population lineage.
By relating, the fluorescence intensity measured between two time intervals to a transfer function we are able to deconvolve the inheritance of cellular material during mitosis.
In summary, we have presented a transfer function method for determining the inheritance of cellular material; the partitioning of endosomes loaded with colloidal quantum dots between daughter cells has been measured using flow cytometry.
The use of a transfer function approach allows us to utilise high throughput measurement of large cell populations to derive statistically relevant measurements of the inheritance of cellular material.
The purpose of this paper is to outline a method for assessing the inheritance of cellular material using high throughput fluorescence measurements combined with simple and more accessible models derived from systems theory.
Although many of the students we surveyed were able to describe accurately the process of natural selection and the inheritance of genetic material, they often faltered when asked to describe the process by which mutations can alter phenotype and how variation in this process can be selected over generational time.
The analysis can only measure the inheritance of labelled cellular material and therefore the inheritance of any new cellular material which develops during the cell cycle cannot be elucidated upon.
Sexual dimorphism, the differences in appearance between males and females of the same species, such as in colour, shape, size, and structure, that are caused by the inheritance of one or the other sexual pattern in the genetic material.
Wickham, The Inheritance of Rome, pp. 279-297.
Wickham, The Inheritance of Rome, pp. 298-317.
