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Given the indispensable function of the β -chain in IL-2 signaling of T cells, diminished expression may contribute to disturbed immune homeostasis in AAV.
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Evaluation of the role of these oxylipins in providing plant protection against two necrotrophic pathogens, B. cineara and A. brassicicola, further illustrate the indispensable function of jasmonates, and not C6-aldehyes in mediating the activation of direct plant-defense responses.
The treatment with anti-IFN-γ antibodies completely restored the proliferation of T cell blasts co-cultured with MSCs supplemented with SupCD3-act, thus confirming the indispensable function of soluble IFN-γ in T cell proliferation.
These findings show the indispensable function of Bcl-2, Bcl-XL and Bcl-w as resistance factors that protect from intrinsic pathway-induced cell death in a subset of SCC cells.
One of the indispensable functions of government national defense has made governments the most important consumers of goods, and they have not hesitated to use their resulting pricing, purchasing, and contracting powers to achieve various economic aims.
With the recent discoveries regarding the indispensable functions of vitamin B12 and folate in living organisms [ 1, 2, 7], it comes as little surprise that vitamin B12 and, to a lesser extent, folate, maintain their levels throughout our life cycle or else the participating subjects would not have been able to enter the study in advanced age under the classification 'healthy'healthy
Immanuel Kant said, "Imagination is a blind but indispensable function of the soul without which we should have no knowledge whatever but of which we are scarcely even conscious".
Kant describes the function he had in mind as "a blind but indispensable function of the soul" (A78=B103), so he meant something rather different from what we now mean by the term 'imagination' (A120 and fn).
Interestingly, we also identified an indispensable function of Rad52 in the repair of DSBs at CFS-derived AT-rich sequences, despite its nonessential function in general homologous recombination (HR) in mammalian cells.
The transplantation of autologous adult epidermal stem cells is a life-saving procedure as it regenerates the indispensable barrier function of the skin, but the reconstruction of fully functional skin has been hampered by the complexity of the process.
The nature vs. nurture argument reminds us that both genetic and epigenetic information is indispensable for the normal function of the brain.
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