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The AID of nutrients was determined by the indicator method.
Apparent ileal digestibility coefficient of P was determined by the indicator method and linear regression was used to determine true ileal P digestibility.
As noted, the indicator method is of general utility and could readily be applied to longer sequences or concatenated multi-gene alignments without substantially increasing computation time, which might address some of these limitations.
We used the indicator method to deal with covariates with missing values in the Cox regression model (Greenland and Finkle, 1995).
Therefore, to ensure that positive results were not biased by the use of the indicator method, we used multiple imputation for variables with over 10% missing data.
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The fixed effects will consist of the baseline of the outcome using the missing indicator method and any remaining minimisation stratifiers, including study site.
Observations with missing data for covariates were retained in the analysis using the missing indicator method for variables missing greater than 1% of the observations [20].
For models with missing covariates, we tested three different methods (missing indicator, imputed with median, and assuming no change from before to after MI periods) with similar results, and therefore we present only the results using the missing indicator method.
In addition to the high accuracy of the optical measurement system, this system is much easier to use in comparison to the dial indicator method, because the passive markers are self-adhesive and, as mentioned, can be attached nearly anywhere.
The most extensively used method at the Mexico Children´s Hospital Federico Gomez1 is the carpal indicator method (Björk method).
Those participants missing the baseline value will remain included in the analysis by using the missing indicator method, which is valid for pre-randomisation measures in trials [ 69].
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