The findings also indicate the importance of conservativeness in prescribing opioids to this group of patients, especially if the indication is gastrointestinal symptoms, because opioids appear to have no or weak effect on these symptoms.
The FDA said the indication was "not approvable", in part because "there appear to be some publicly available data on the ASR that suggest somewhat poorer results for the device than results suggested by the data you submitted".
Crossover to another extraction technique was not attempted in 3/7 of these leads (two laser and one manual) because the indication was not Class I.
"Obviously we are tremendously concerned about this, because all of the indications is this could be millions of dollars in fraud," said Glendale City Manager Jim Starbird.
But don't get your hopes up, because all the indications are that the average handouts are going to be in the hundreds rather than thousands of pounds.
While the famous Aintree race will be an hour later than previously at 5.15pm from next year, the indications are that this was a decision made because of the particular circumstances of a unique contest and need not be repeated elsewhere.
They recognized that there is evidence for short-term efficacy of testosterone in selected populations, such as surgically menopausal women, but advised against the generalized use of testosterone by women, because the indications are inadequate and evidence of safety in long-term studies is lacking (Wierman et al 2006).
But Lee's contemporary Truman Capote might provide a better analogy for the club's prospects in 2014 because every indication is that they'll be murdered in cold blood.
That indication is important because current prostate cancer biopsies are random and highly subject to sampling error.
Treatment indication is also important because some antipsychotics, particularly quetiapine in low doses, may have been used to treat insomnia rather than core symptoms of schizophrenia.
A formal consensus on this was not issued, seeing as this indication is very rare in childhood, because the overwhelming majority of pediatric patients have markedly fewer attacks.
