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The Primal congestion control is the source node dynamically adjusting the sending rate or window sizes depending on the indication information fed back from the Internet.
We used the indication information by 2009 from the drug labels from the Drugs@FDA database (http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.Search_Drug_Name) to generate a list of drug-cancer associations (Dataset S1) that included 23 types of cancer.
Most reports using medical records derive indication from the procedure report alone and in some cases the source of the indication information in the medical records was not clearly described [ 18, 33- 36].
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We found that, although the direction of the association between screening colonoscopy and late-stage CRC diagnosis risk was not changed by the indication data source, analyses with information from the progress notes alone or in combination with referral and procedure reports produced results that were closest to those from the indication derived through adjudication.
Compared with ANCC, FANCC requires the destination to broadcast 2m bits for the relay and transmission indication information, but the additional cost in the indication phase could be ignored if the length of broadcast-packet is large, which can be implemented easily and has great practical value.
Given the known lack of recording of indication information, the former pattern appears to be the more useful; yet the latter pattern appears to have more extensive use in eligibility criteria.
Drug indication information from the FDA adverse event reporting system (FAERS) was downloaded from the FDA website [ 24], where the indication of a drug were linked to the drug name via the fields ISR and DRUG_SEQ The drug names in FAERS were mapped to pipeline® drug names via drug synonyms field in the pipeline® database.
The DrugBank database stores drug data with corresponding drug target and treatment indication information [38].
However, although nontherapeutic effect information of the types seen in the eligibility criteria is available for medicinal products as part of this authorisation information, it is not as organised and as accessible as the categorical characteristics or indications information nor is it standardised.
We further verified the indication and usage information of these drugs using their FDA label files.
In addition to the clinically valuable information embedded in the imaging findings related to the chest CT indication, incidental findings that are unsuspected or unrelated to the indication contain prognostically valuable information about multiple diseases [ 3– 5].
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