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The internist, instead of carefully reviewing her medications for possible side effects, reducing dosage, checking content levels in the blood or considering the possibility of dehydration, had prescribed more drugs to medicate the increasing side effects, thereby speeding her decline.
"Starting two years ago, we are on the increasing side of the solar cycle," Kunches said.
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This may result from increased steric hindrance between the aromatic substrate and the aliphatic residue owing to the increased side-chain size.
C139 and C147 were mutated to aspartic acid (C139D/C147D), with their β-carboxylic acid mimicking the increased side-chain volume and negative charge of sulfinic acid.
The Trp mutation further increases side chain bulk, whereas Ala decreases the size and removes the functional property of the side chain carboxylate.
The danger of aiming for the host could be increased side effects.
Hence the increased body side to side motion which is often described anecdotally as "waddling gait can be observed.
In the other two studies using amoxicillin-clavulanate showed considerable benefit although at the cost of increased side-effects [ 26, 27].
Given the same composition ratio, the increased oxyethylene side chain length is beneficial in enhancing CO2 permeability.
The increased high-side pressure has a positive effect on the system performance and outweighs lower ejector efficiencies.
On the other hand, choosing λ≪1 reduces the central distortion at the price of increasing the side distortion.
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