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The studies on cellular uptake and biodistribution indicated that the better antitumor efficacy of tSLNs was attributed to both the increased accumulation of drug in tumor and more cellular uptake by hepatoma cells.
The increased accumulation of thermoprotectants in yeasts occasionally leads to increased thermotolerance.
The increased accumulation of PFOS may explain the higher toxicity of this substance [144].
The increased accumulation of sugars in peppers appeared to be strongly associated to the level of ascorbic acid.
The increased accumulation of MeJA activates the expression of OsSDR, which results in the high level of ABA biosynthesis.
The increased accumulation in the DNA of Mutyh−/− mice was 2-fold higher (Figure 7A).
The increased accumulation of collagen I and III has been associated mostly with fibrosis [18], [19].
The increased accumulation of intracellular drug may be a result of decreased expression of Pgp1 or decreased function of Pgp1.
The increased accumulation of Aβ42 in lysosomes of LRP1-expressing cells (Fig. 2B) and its correlation with decreased cell viability (Fig.5) is intriguing.
The increased accumulation of GUS loop mRNA in the rdr6 mutant compared to wild type provides additional confirmation that degradation of the loop occurs via transitive silencing.
The increased accumulation of SZP was confirmed by immunochemical localization.
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CEO of Professional Science Editing for Scientists @ prosciediting.com