Exact(5)
Considering the polymer enrichment in lauryl alcohol, the incomplete release observed for PLGA-capped is likely attributed to interactions between the protein and the lauryl end group.
Firstly, in view of the proposal that syntaxin lines the fusion pore [31], the Kv2.1-syntaxin interaction may promote full collapse fusion, which induces complete release, in place of the incomplete release associated with kiss and run exocytosis.
A number of reasons could cause the incomplete release when double-emulsion/solvent evaporation method is being used as in this study.
For example, one of the possible causes for the incomplete release observed might be due to nonspecific adsorption of peptides to interfaces or to microsphere materials.
Colloid remobilization during washing was probably facilitated by the incomplete release of adsorbed Ca2+ between the colloid and the substrate during the flowback fluid flushing stages for Experiments B C with "flowback fluid flush".
Similar(55)
Mr. Simon has been unable to capitalize on Mr. Davis's fund-raising controversy because of problems of his own, including a fraud judgment (later overturned) involving a failed telephone venture, the tardy and incomplete release of his income-tax returns, and the use of legally murky offshore accounts to trim his taxes.
Compared with free DOX, DOX-loaded micelles exhibited much lower cytotoxicity to HepG2 cells at the same dose of DOX, which was mostly due to the controlled and incomplete release of DOX from micelles in this time frame, as confirmed with in vitro DOX release.The cellular uptake of the micelles was further examined by CLSM measurements.
Burst or incomplete release of the therapeutic agent and the poor scalability of the manufacturing process represent other limitations in the use of hydrogel as drug delivery systems.
An "immediate" and complete release of API from the anionic (Eudragit® L100), and "sustained" but incomplete release from the hygroscopic non-ionic polymer coatings were observed.
However, the impermeability of the PMMA to the antibiotic(s) to a large extent results in a slow and incomplete release of the antibiotic(s) and, sometimes, failure to reach minimal antibiotic concentration [ 6, 8].
Higher concentrations of sodium bicarbonate (F numbers 17 and 18) reduced drug release to a level sufficient for incomplete release after the 24-hour period.
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