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If the brain is hyperexcitable the incomplete circle of Willis may not provide satisfactory blood supply, which may result in ischemia and cortical spreading depression [6].
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In the present study we compared the prevalence of incomplete circle of Willis in female migraine patients without aura to female healthy non-migraine controls.
We found no difference between the prevalence of incomplete circle of Willis in patients, 20/47 (43%), and controls, 15/37 (41%), p = 0.252.
Our study confirms a recently published study by Cucchiara and colleagues [8] who also found no difference in the prevalence of incomplete circle of Willis between migraine without aura patients and controls.
The primary endpoint of the study was to compare the prevalence of an incomplete circle of Willis between migraine patients without aura and healthy controls.
Additionally and independent of the commissures, one transverse nerve anterior to the pharynx forms an incomplete circle including only lateral and dorsal peripheral longitudinal nerves and three closed rings include all longitudinal peripheral nerves at the level of the seminal receptacles.
This can partly explain the slightly higher prevalence of incomplete circle of Willis reported by Cucchiara and colleagues [8] compared to the present study.
It should look like two short vertical convex lines, like an incomplete circle, between the top and bottom eye lines.
The proposed relationship between migraine and an incomplete circle of Willis is that it might cause decrease in regional cerebral blood flow.
The images were subsequently analysed blindly by a neuroradiologist to detect incomplete circle of Willis.
Historians have long debated whether Stonehenge was a full or incomplete circle, with some arguing a lack of stones in the south-west quadrant is proof it was never complete.
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