The main reasons for ineligibility included inaccurate diagnosis (for 51.5% of ineligible patients: benign or second cancers, or errors in ALD file regarding the tumour site), inappropriate delay between diagnosis and survey (for 21.7% of ineligible patients: in most cases late recording in the ALD file), and patient death before the survey (for 16.4% of ineligible patients).
This is a clinically relevant point, since an inappropriate delay in MV is known to compromise its efficacy and the patient's clinical outcome.
Inability to early identify patients who will fail NPPV can cause inappropriate delay of intubation, which can cause clinical deterioration and increase morbidity and mortality.
Therefore, it would be advantageous to identify patients with chemosensitive tumors before initiating NAC, to avoid potential therapy-related complications and an inappropriate delay of surgical treatment.
9 However, for patients arriving early in hospital, inappropriate delay may occur prior to being seen by a physician and performing a CT scan; inefficient in-hospital management might preclude candidates for thrombolysis.
In conclusion, this study shows that the inappropriate and delayed empiric antimicrobial therapy and single initial antibiotic therapy in patients with cirrhosis and septic shock is associated with significant increase in hospital mortality.
It was shown in [40] that inappropriate delays could degrade the performance of the algorithm.
"Frequent, unnecessary and inappropriate delays characterized the Wen Ho Lee investigation".
For example, sea level rise poses very real risks, but talking-up the certainty of rapid and catastrophic rises could lead to investment in flood defenses unnecessarily early, while down-playing the risks could lead to inappropriate delays.
The exclusion criteria were: treatment with amikacin within 7 days prior to inclusion; inappropriate dose of amikacin (<27.5 or >32.5 mg/kg); inappropriate duration of amikacin infusion (<25 or >35 min); and inappropriate delays in measuring the amikacin C max (<20 or >40 min after the end of infusion).
