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Future investigation needs to confirm the implication of these genes in urinary bladder cancer.
Further investigations are underway to estimate the implication of these genes in mammalian folliculogenesis.
However, it will be necessary to carry out association and functional studies to demonstrate the implication of these genes in normal pigmentation variation.
However, it will be necessary to carry out association studies in samples for which quantitative data on pigmentary traits are available, and functional studies in melanocytes to confirm the implication of these genes in normal pigmentation variation.
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The implications of these genes, at the CC level, deserve to be addressed in future studies in order to understand their function in follicular growth.
Although the implication of these candidate genes is only a preliminary finding, and validation by microsatellite analysis in a larger cohort of samples would be required in order to definitively link them with the pathogenesis of NHL, they clearly illustrate the utility of the CHC method for derivation of LOH candidates.
The implication of the genes ompT and hlyF in the virulence of APEC should be investigated to better understand the pathogenicity of these strains.
No evidence for the implication of the genes in cancer or autoimmune states has been reported for the remaining antigens.
With regard to the implication of this gene in unusual phenotypes, we report a family presenting with congenital nystagmus, foveal hypoplasia, and iris hypoplasia or atypical coloboma.
We used mice heterozygous for a Dyrk1A targeted mutation (Dyrk1A+/−) to investigate the implication of this gene in the cognitive phenotypes of monosomy 21.
We investigate the potential implication of these genes in interdigit remodeling because of the role of this gene family in the regulation of proliferation of cancer cells and neural stem cells.
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