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These results suggest that increased wild-type UCMK expression does not provide a significant enhancement in dFdC-mediated cytotoxicity and may warrant the implementation of studies aimed at engineering UCMK variants with improved activity toward gemcitabine monophosphate.
There is nevertheless still scope to improve the study design, the implementation of studies and their analysis and reporting in conflict settings.
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Here we describe details of the implementation of Study-II concepts and discuss their efficacy.
MD contributed to the implementation of study in Georgia and comments on the manuscript.
MD, GG and AZ contributed to the implementation of study in Georgia.
The implementation of pilot studies of this kind requires the availability of a high throughput method.
P.M. contributed to the implementation of the study, conducted field data collections and manuscript editing.
H.A.B.P. contributed to the implementation of the study, conducted field data collections and manuscript editing.
FY and SM assisted in designing the study and supervised the implementation of the study.
GV participated in the design of the study, and participated in the implementation of the study.
RB developed the study design and managed the implementation of the study.
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