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The identified path is equivalent to the composed solution.
As shown in Movie S1, when permeating along the identified path, Na+ ions have to pass through D (Asp375) and E (Glu701) in the DEKA region.
As shown in Figure S6, contour envelopes covering 90%, 80 %, 70 % and 60of the density points are all distributed around the ridge, which supports the "most probable" property of the identified path.
The identified path has been experimentally proven to exist in the yeast cells.
The identified path explains how the TF may regulate this target either directly by binding to its promoter or indirectly through intermediate TFs.
The identified path might explain how the TF regulate this target either by binding to its promoter directly or by a transcriptional regulatory chain through intermediate TFs.
Similar(51)
The angles and delays of the identified paths at 14−16 and 28−30 GHz are quite similar both for the LOS and O-LOS scenarios.
However, the normalized power values of the identified paths with same delay and angle at different frequency bands might be different.
The identified paths form experimentally testable hypotheses regarding the molecular mechanisms of how a TF may regulate its knockout targets.
To gain a complete understanding of the full metabolic response requires either extrapolation about the identified paths or the further refinement of the hypothesis through explicit specification of start and end compounds.
Moreover, the identified paths from the knocked-out TF to its knockout targets in the TF binding network form experimentally testable hypotheses of how a TF may regulate its knockout targets.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com