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The identification of interfaces between partner molecules provides targets for pharmacological intervention; the protein-protein interaction surface between Bcl-xL and cytochrome c here identified may offer one of these targets.
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The identification of interface sequences may also help in the de novo design of functional proteins and peptides.
Additionally, the identification of the interface between telomerase and the telomere will allow more targeted approaches to alter telomerase recruitment as a potential therapeutic approach for human diseases.
The identification of protein interfaces has been based on several criteria such as solvent accessibility (ASA), distances cut-off, conservation residues [12], [13], [14].
It allows for the identification of interactions between design variables.
The identification of appropriate clusters of interface residues provides starting points for inhibitor design and supports an overall assessment of the susceptibility of PPIs to small-molecule inhibition.
Yet, despite the identification of numerous molecules at the interface between endocytic machinery and the cytoskeleton, our mechanistic understanding of how F-actin regulates endocytosis remains limited.
Moreover it enables users to batch-process large data sets, simplifying the identification of commonly regulated sites between cross-species experiments with an easy-to-use web-based interface.
The identification of the residues of these interfaces is rather difficult.
2. The intuitive graphical user interface available on PlasmoDB allows for the identification of sets of results that are common between or unique to specific ICEMRs.
The present additional insight aims to improve the identification of Au/Pt migration along the Ti-Si3N4 interface.
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