At the end of this prediction step, we checked whether each predicted product (found by applying the chemical transformation to the substrate) is already listed in BRENDA or KEGG, by looking for an identical compound (see Section 2.1).
The potential beneficial effect of monoclonal antibody therapy against EVD was reported in a recent experience describing the clinical management of few EVD patients treated with ZMapp (a similar, though not identical compound) [ 9, 10].
Hence, compound descriptors explain a large proportion of the variance, which may stem from the high correlation of the bioactivities of identical compounds against orthologs.
This XY CPM is composed of identical compound basic parallelogram modules as non-under-constrained compositional compliant modules, which is completely-kinetostatically decoupled.
To date, the best-studied family affected with TPI deficiency is a Hungarian family in which two germ-line identical compound heterozygote brothers have inherited a missense mutation at codon 240 encoding the Phe240Leu TPI variant and a nonsense mutation at codon 145 (GleadingR) leading to a truncated TPI protein [18], [19].
Noteworthy, a chemically identical compound ASO (ISIS 141923) without known complementarity to any known gene sequence was used as a control ASO.
For example, the two structurally identical compounds pancuronium and vecuronium (TC = 1) are competitive nicotinic antagonists but exert opposite transcriptomic responses (Cor = −0.14, P < 0.01) under the same condition (cell line: PC3, dose: 10 μm, time: 6 hours).
Styrene is one of the identical xenobiotic compounds and serves as a potent toxic pollutant to the environment as well as human health.
More substances provide more evidence, even when the substances are supposedly identical compounds.
Sensitivity analysis excluding those trials that compared a triplet versus a doublet without the presence of two identical compounds in both arms showed a lower HR for OS of 0.79 (95%% CI 0.71 0.88 (Fig. 8)).
