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This showed for the first time that it was possible to find a scenario of inversions consistent with the human strata, at least the most recent ones (i.e., strata 4 and 5).
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It will probably appear instantaneous, and it will be very hard work to figure out the path of this hyperevolution of the technofossils within the human stratum. .
Our Western blot analysis of human stratum corneum extracts demonstrated that the main DNase of the human stratum corneum was not identical to DNase1L2, which has an activity optimum at pH 5.6 [12] (Suppl. Fig. S1C).
The human stratum corneum (SC) is a superficial continuous membrane made of tightly stacked corneocytes parted by multilamellar lipid sheets.
However, the only translocation that has affected the human stratum 3 seems to be the translocation of the entire XAR (see Ross et al. 2005), and it is not clear why this would have stopped recombination at some part of XAR (e.g., stratum 3) and not others (strata 5, 4, and the current PAR).
This may be due to a wrong definition of the strata 3/4 boundary, to the formation of stratum 3 by a mechanism different from Y inversions or more likely to the existence of several strata (maybe two) within stratum 3 (see section on discussing the case of the ancient human strata).
This, of course, weakens the conclusion on the evolution of human strata from the GRIMM results.
Our results strongly support the view that the most recent human strata have arisen by Y inversions and suggest that inversions have played a major role in the differentiation of our sex chromosomes.
We discuss the case of ancient human strata.
There is reason to believe that the greater frequency of canid and mustelid remains in early modern human strata reflects the use of garments with fur trim.
Because the fitness dream is unlike all other human strata: it's meritocratic.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com