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Subsequently, emulating the human scenario, all mice underwent complete tumor excision and were allowed to recover, with attendant metastasis development.
It is also apparent that the results of such animal studies are not wholly predictive of the human scenario [35].
This is impinging the translation of animal findings to the human scenario.
Another important aspect is whether these data are recapitulated in the human scenario.
We reasoned that it would be important to carry out additional B 9-23/IFA immunisation studies at a later, more advanced stage of the disease (9 weeks old and recent-onset) in order to better reflect the human scenario, where prediabetic patients with different degrees of beta cell loss and targeted autoantigens are being recruited.
Rather than attempt to replicate the human scenario, most animal bioassays aim to standardize these factors in test animals in order for the contribution of treatment to toxicity and carcinogenic effects to be more readily observed (Bucher 2002; Melnick et al. 2008; NTP 2011a; U.S. EPA 1998).
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However, the FPR depended on the family structure in the data, with a greater degree of relatedness for the pig scenarios than the human scenarios.
We then scaled it up and simulated the situation to human scenario and found that the model prediction is consistent with those observed from the empirical data.
This study has several limitations: the relative paucity of the sample and the results obtained may not be directly translated into human scenario.
Certain patterns emerge that are consistent with the "human only" scenario.
Still, results from animal models are not directly applicable to the human clinical scenario.
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CEO of Professional Science Editing for Scientists @ prosciediting.com