Sentence examples for the human checkpoint from inspiring English sources

Germline mutations in the human checkpoint gene, hCHK2, were first identified in 1999 in cases of Li–Fraumeni syndrome.

The phosphorylation networks we construct, centered on the human checkpoint kinase BUB1B (BubR1) and its yeast counterpart MAD3, offer a unique view of the spindle checkpoint that emphasizes biologically relevant phosphorylated forms, phosphorylation-state specific phosphorylation-state specifictionshiPPIs

Specifically, we build a phosphorylation network centered on the human checkpoint protein BUB1B and show that it provides a different, but complementary view of the spindle checkpoint from existing protein interaction network building tools.

Alternatively, working out the role of the Ndc80 complex in checkpoint control is challenging: for instance, only when levels of hNDC80 complex subunits were depleted below ∼1% of wild-type level was the human spindle checkpoint inactivated [56].

Information about the human spindle checkpoint proteins BUB1 and BUB1B, and their yeast homologs BUB1 and MAD3 was captured through a combination of text and data mining approaches.

Chen and Wang [ 36] recently reported that the stabilization of p53 conformation after heat shock is associated with its binding to Hsp90 protein and that the phosphorylation of p53 is dependent on the Ataxia-telangiectasia-mutated protein kinase (ATM -mediated ATM -mediated humactivationint 2 (ChK2) kinase.

We developed a theoretical model of the human biochemical mitotic checkpoint at meta- to anaphase transition.

As a first attempt to study SAC during the plant cell cycle, candidate A. thaliana orthologs of the human essential mitotic checkpoint complex proteins BUBR1, BUB3 and MAD2 were identified by OrthoMCL [13] clustering of orthologous proteins from six model eukaryotic species.

The strength of the IsoCleft and the IsoCleft Finder interface can be seen with the Human mitotic spindle checkpoint kinase Bub1 (PDB code 3e7e) query protein in Figure 6.

There was the police officer who was persuaded not to harass a market woman on her way through a checkpoint, the human rights seminar that was attended by dozens of soldiers, who nodded when Father Costa urged them to respect their fellow citizens.

Tel1 is the yeast homolog of the human ataxia telangiectasia (ATM) checkpoint protein, primarily involved in telomere length regulation [37], [38].