In order to obtain the most informative sequences, the amplicon with the highest size for each DRT primer mix in each applied DNA walking method was selected to be sequenced (Additional file 5).
Under these conditions and without misclassified causes of death, the results in Figure 4 (see also Additional file 1: Figure A.6 and Table A.5) suggest that Gr has the lowest power for CD (0.54 < 1- β < 0.93 for Gr, while 0.86 < 1 - β for Pe and CS; complete data) and often by far the highest size for NCD (0.16 < α; complete data).
The highest size reduction rate is observed for pristine oxo-G, which bears the highest degree of functionalization of around 60% and the negatively charged organosulfate group.
The drugs with the largest effect size for vertebral fractures were zoledronic acid, teriparatide and denosumab, while the drugs with the highest effect size for non-vertebral, hip or wrist fractures were alendronate or risedronate.
Paralysis, faints/blackout, breathlessness, and pain were the impairments with the highest effect size for less wellbeing.
For each, we gathered allele frequencies for Europeans and East Asians from either public databases (HapMap, ALFRED or dbSNP) or, if not available, from the paper with the highest sample size for each Continental population.
With respect to the high effect size for novel programs, it may be that a novel program encompasses the greatest possible fit to the context where it takes place.
These two studies were the ones with the highest effect sizes for cognition and activities of daily living outcomes and had extremely low drop-out rates.
In a meta-analysis of data from 1,136 patients and 1,401 controls, the ENIGMA-Schizophrenia Working Group found that hippocampal volume gave among the highest effect sizes for any subcortical brain structural difference in schizophrenia (Turner et al. 2013; van Erp et al. 2013).
The highest genome size value for T. boeoticum was observed for the Türkoğlu population (BOE-53, 6.310 pg), followed by BOE-6, BOE-33 and BOE-16; the smallest value was noted for the Narlı population (BOE-56, 6.167 pg).
All tests demonstrated responsiveness to change, however the highest effect size was seen for the PFIT-s: The effect sizes of the PFIT-s and IMS were 0.71 and 0.59 respectively, which represent a moderate responsiveness to change.
