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In Bahrain, finally, the country with by far the highest linkage density with Saudi Arabia, Saudi-led military intervention helped put down the uprising.
Affected individuals in the demographically ancient isolate of ethnic Dargins (No. 6022) who suffered from disorganized schizophrenia showed the highest linkage evidence at 17p11 p12 (LOD = 3.73), while isolates with a predominant aggregation of paranoid schizophrenia (Nos. 6005, 6011, and 6034) showed the highest linkage evidence at 22q11 (LOD = 3.0 and 4.4).
Similarly, the highest linkage peaks for both coat colour and speckling were mapped to this chromosome.
In a previous meta analysis of three genome screens in the American, British and Canadian populations [9], this region had the highest linkage score for MS outside the MHC, with a non parametric logarithm of the odds (LOD) score of 2.58.
For the tag-SNPs showing the highest linkage disequilibrium with the identified copy number variants in the population where the CNV was identified, we obtained the global and pairwise FST values among populations for the Phase II HapMap SNPs from [84].
The SNP with the highest linkage within the QTL found on chr.
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Due to the high linkage disequilibrium in the region and the extensive polymorphism in exon 2 (which encodes the antigen-binding domain), genetic typing of this exon is likely to detect most of the variation in the locus.
The individual contribution of genes in the HLA region to the risk of developing type 1 diabetes (T1D) is confounded by the high linkage disequilibrium (LD) in this region.
Due to the high linkage disequilibrium in the MHC region, only a limited set of DQA1*-DQB1* haplotypes (DQ types) are observed in the general population (see http://depts.washington.edu/rhwlab/resMat/dq/linkage.html for an example of common combinations of DQA1* and DQB1* alleles in the Caucasian population), resulting in only a few instances that did not correspond to canonical DQ types.
Thus, it is possible that the association between G1287A polymorphism and the MPH-induced changes in omission errors results from the high linkage disequilibrium with these SNPs.
Nevertheless, the variability at the ospC locus, along with the high linkage among all genetic loci [ 12– 15], makes ospC a good marker to delineate different B. burgdorferi lineages.
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