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Given that the higher level selection does operate, the selection at the lower levels, if allowed, can produce nothing but casualties like a parasitic DNA or a malignant cell.
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Such a novel higher level selection pressure is revealed in the case of straight moving pairs (sPAIRS) invading a population of turning pairs (tPAIRS) (see Figure 7a).
Finally, serendipity serves as a higher level selection mechanism that pushes forward new ideas and opportunities for further research.
Higher level selection emerges from lower level reproduction.
In his writings [ 16, 119], Professor Doolittle acknowledges the problem of high level selection.
This assumption is often based upon the high level purifying selection within most DNA binding domains, whose conservation across species is often stronger than other parts of the protein factors (Hirsch and Aggarwal 1995; Luscombe and Thornton 2002; Rorick and Wagner 2010).
At the higher level, supported by anterior DLPFC, action selection is based on episodic control, taking into account the ongoing temporal context.
If it is not trumped by the higher-level selection, the species simply will not go through.
Despite differences between my viewpoint and Professor Doolittle's on the topic of high-level selection, I would like to mention that I have found his publications on evolvability in the contexts abovementioned inspiring.
Discussing the possibility of explaining TEs by high-level selection, they write: "The selective advantage represented by evolutionary adaptability seems far too remote to ensure the maintenance, let alone to direct the formation, of the DNA sequences and/or enzymatic machinery involved.
While considering these options, Professor Doolittle consistently admits the relative weakness of high-level selection, implying the untenability of maintaining a trait by high-level selection in the face of noticeable individual-level costs, and he carefully constructs his arguments in a manner that recognizes this problem.
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