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Because of the technical complexity associated with delivery of 24 Gy in a single session, there has been an ongoing search for tumor radiation sensitizers that would enable use of lower dose per fraction via currently affordable technologies, preserving the improved outcome provided by the higher exposures of single dose or hypofractionated schemes.
Terminal elimination t1/2 estimates range from approximately 75 days at exposures of 10−3 μg/kg to approximately 10 days at the higher exposures.
The long-term health implications of the higher exposures to OTA for young children are not known and require further investigation.
It is useful to report both central and high-end estimates and to characterize groups likely to be affected by the higher exposures.
At the lower exposures, the half-life of TCDD is > 10 years, and at the higher exposures the half-life is only weeks.
Based on these past models of teratogenicity, the higher exposures represented by daily maxima could be more relevant to disruption of cardiac development.
Similar(49)
Despite all the increased money, the better players, and the higher exposure, ordinary Russians do not seem to be responding.
It does have an altimeter, a nice feature that accounts for the higher exposure you'll get in the mountains.
The higher exposure temperatures result in larger damage zones for both the low and high impact energies.
The higher exposure temperatures were selected to accelerate the degradation of the coating by interdiffusion with the substrate.
The higher exposure among farmers and fishermen is also borne out by the age distribution of the disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com