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The high sequence variability suggests that somatic diversification of these nonself recognition molecules could have occurred.
Filtering was required due to the high sequence diversity (on less conserved regions) resulting in a high number of gaps in multiple sequence alignments.
The high sequence and structural similarity within these protein classes suggests a generality of the interaction mode among homologous proteins.
However, the high sequence homology between D3R and the D2 receptor (D2R) challenges the development of D3R-biased compounds.
The high sequence conservation within Pf strains and the fact that antibodies taken up by mosquitoes in blood meals can impede parasite development make Pfs25 an attractive TBV target.
The high sequence similarities between shared ISVs from Cairns and Bangkok were also clearly evident when phylogenetic trees were generated from the protein sequences of the RNA-dependent RNA polymerases (RdRps) encoded by the assembled contigs (Fig. S2).
Despite the high sequence similarity, the expression level of this protein was much higher in NH04 than in NBRC3832.
Despite the high sequence homology between PSA and hK2, the 11B6 antibody did not show any cross-reactivity to PSA.
Therefore only the high sequence similarity was taken in account.
Another assembling problem is posed by the high sequence similarities among closely related species.
SAA1 and SAA2 (SAA1/2) were analyzed as one transcript because of the high sequence homology.
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