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The primary objective is to determine the effectiveness of a systematic osteoporosis screening and treatment program on the hazard of developing a fracture over the treatment period.
The hazard of developing a breast or ovarian cancer hbo(x) is therefore a mortality hazard.
These risk factors translate into a substantially increased risk of morbidity and mortality; for example the hazard of developing a myocardial infarct in early-onset T2DM (< 45 years) is 4-fold higher than in late onset T2DM (> 45 years) and 14-fold higher than in people without T2DM [ 6].
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The case of Geron, the biotechnology company that has been the first to initiate a clinical trial using ESC-derived cells, illustrates the hazards of developing a cell-based product [ 3].
Based on the width of the confidence intervals presented in Table 3, we can exclude (with 95% confidence) a >24% increase in the hazard of developing CHF and a >51% increase in the hazard of developing CVD per 1 SD increase in sex-standardized log-leptin in models assessing incremental contribution of leptin levels over BMI.
The West of Scotland Coronary Prevention Study reported a 30% reduction in the hazard of developing diabetes with pravastatin.
In the present analysis, the triple negative phenotype brought about a dramatic increase in the hazard of developing bone metastasis with statistical significance compared with ERBB2+ subtype (P < 0.05).
In a study in the Democratic Republic of Congo, ART halved the hazard of developing TB in HIV-infected children [ 55], with a TB incidence rate in those receiving ART of 10.2 per 100 person-years versus 20.4 per 100 person-years in those not yet on ART; after 12 months of ART TB incidence decreased to 5.3 per 100 person-years.
In contrast, the West of Scotland Coronary Prevention Study WOSCOPSS; n = 5,974) showed that, compared with placebo, pravastatin was associated with a 30% reduction (P = 0.042) in the hazard of developing T2D after 5 years [ 13].
When adjusting on age, sex and proximity to case, all factors independently associated with development of TB in contacts of TB cases [15], the hazard of developing TB was 1.5 greater when TST response was >10 mm and 2.6 greater when TST response was >15 mm.
In men, the hazard of developing hyperuricemia remained constant.
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CEO of Professional Science Editing for Scientists @ prosciediting.com