In the mammalian heart, this gradual developmental loss of cardiomyocyte proliferative capacity, leading to a transition from hyperplastic to hypertrophic growth, has been attributed to a block in the cell cycle with the majority of adult cardiomyocytes blocked in the G0/G1 phase of the cell cycle.
However, as the animal grows up towards adolescence, a gradual developmental change occurs in the balance of neuroimmune regulation towards a pro-inflammatory response, perhaps to protect against foreign invasion, which dominates and allows the expression of neuronal sensitization and the appearance of pain like behaviour.
The authors found evidence for a gradual developmental progression from less serious to serious antisocial behaviours along three pathways identified as overt, covert and authority conflict pathways.
Her gait is broad based, but she is the most confident of her siblings, and has shown gradual developmental progress.
While this work focused on up- or down-regulation of gene expression between these two culture types, the focus was not on assessing gene expression associated with gradual developmental changes during MS formation.
For example cytokine analysis of LPS-activated microglia between P0 to P49 mice reveal a gradual developmental shift to a defence-orientated M1 phenotype, with an increasing induction of TNF-α, IL-1β, IL-6 and a decline in arginase with age (Scheffel et al., 2012).
We also noticed that these cell lineage trajectories represent the gradual loss of developmental potency or potential of cells (Fig. 1B).
Their locations near the bottom of all three trajectory lines also support the general trend that these cell lineage trajectories represent the gradual loss of developmental potency of cells (Fig. 1B).
In addition, unique physical features such as the presence or absence of a placental barrier and the gradual development of the blood--brain barrier influence chemical disposition and thus modulate developmental neurotoxicity.
The gradual disappearence of early developmental markers such as PSA-NCAM and DCX can be interpreted as a normal process of cell differentiation in postnatal/adult neurogenic systems [9] [11], [43].
