The generality of process-based models, however, comes at a cost of greater complexity, and potentially reduced precision (Levins [1966]; Sharpe [1990]).
However, there are several weak points in their approach [ 17], and we suggest that their conclusions are open to alternative explanations and yet different approaches should be adopted to test the generality of processes affecting the distribution of clonal ages.
15 The generality of this process was next investigated (Table 2).
Indeed, to address the generality of underlying process, it may be a good idea to pool young and old complexes into single analysis.
Moreover, it provides the opportunity for assessing the generality of the process of genome size reduction in three kinds of symbiotic lineages that have different gene content shaped by specific nutritional needs of their insect hosts.
This suggests that both processes affect the age distribution reported by Neiman et al. [ 17] differently in young versus old taxa, which contrasts Neiman et al.'s conclusion about the generality of underlying process.
Complementing measurements of gross toxicity with molecular profiling and genomic studies can make plain the modes of action of specific xenobiotics and identify the generality of biological process affected as well as the molecular response pathways invoked [ 4- 8].
The new data confirms our theoretical predictions and further elucidates the mechanism of the mtDNA bottleneck, while also providing valuable insight about the generality of this process in genetically distinct systems.
It is also observed at low frequency in nontreated lymphoma and HeLa cell lines., The generality of this process for tumor evolution (also termed 'neosis', or the 'cancer life cycle', ) was suggested previously, although still remains to be shown for human tumors in vivo.
Furthermore, such studies do not evaluate the generality of such processes because numerous studies failed to detect higher mutation or parasite loads in asexuals or prove comparable evolutionary plasticity to related sexual populations [[ 5- 8], rev. in [ 9, 10]].
Future RNA-Seq analyses of other viviparous and oviparous squamate reptiles will reveal the extent to which our results represent the generality of genetic processes associated with pregnancy in mammals and reptiles and potentially explain why the transition to viviparity is so easy in squamates.
