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Drosophila testes are generally considered a useful model for studying the fundamental developmental processes of heterogametic organisms.
The Drosophila leg imaginal disc provides a paradigm with which to understand the fundamental developmental mechanisms that generate an intricate appendage structure.
Focusing on the fundamental developmental growth curve of the different brain regions, the authors did not find different trajectories for ADHD affected children or adolescents and controls.
Similarly, Tbx15 is one of the fundamental developmental mesodermal transcription factors that is highly expressed in both human and rodent adipose tissue [ 21].
Hh signalling is one of the fundamental developmental pathways required for correct neural crest patterning (for review see Mishina and Snider, 2014) and disc1 is prominently expressed in neural crest cells (Drerup et al., 2009; Wood et al., 2009), so the craniofacial abnormalities reported in schizophrenia may reflect altered Shh signalling, possibly via DISC1.
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Much controversy existed over how the sperm induces this fundamental developmental event, but growing evidence supports the notion that, during mammalian fertilization, egg activation is triggered by a sperm-specific PLC (phospholipase C) isoform, PLCζ [ 6– 9].
Since these fundamental developmental processes are among the evolutionary most conserved, we hypothesize that the underlying genetic networks and their interaction patterns are also highly conserved.
Based on this fundamental developmental function, we speculate that species-specific microRNAs function in a manner that would contribute to the uniqueness of a species.
Our results also suggest that neuronal maturation is intrinsically linked to neuronal subtype specification and that these fundamental developmental processes are, in large part, coordinately regulated by REST and CoREST.
Spermatogenesis is one of the most fundamental developmental programs related to animal sexual reproduction [33].
Formation of the semicircular canal ducts is a fundamental developmental process, involving the generation of form via movement and fusion of sheets of epithelium.
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