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Low levels of free protein S may further compromise the functioning of the protein C system.
It is unclear how the two mutations in the 26B allele, hot1 P107S,H274Y, could affect the functioning of the protein.
It is therefore supposed that the anchoring of this protein to the tonoplast or plasma membrane may be not essential for the functioning of the protein, unlike with AtFKBP42 that was predicted to be membrane-localized [ 38].
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The first crystal structure of OCP12 had been obtained before the function of the protein was understood.
In those early days, scientists knew the function of the protein and worked backward, taking years to isolate a single gene.
The non-coding RNA promotes recovery from ultraviolet-induced DNA damage, antagonizing the function of the protein product of the coding transcript.
"With this chemical probe discovery, we could look for pinches of magic dust that would modulate the function of the protein," she says.
Next, the function of the protein Cas9 was determined and could be used to cut DNA specifically with engineered RNAs, this was ground breaking(Jinek et al. 2012).
We weren't able to come up with an antibody for the protein". Once the structure and the function of the protein is better known, this newly discovered duplicate protein may have important therapeutic implications.
The attention then shifted to the lipid-protein interface where it was thought that anesthetics may disturb the lipid microenvironment around the protein and thereby change the function of the protein.
Further work is necessary, specifically relating to the function of TANGO2 and impact of specific variants on the function of the protein as this may lead to targeted therapies in affected individuals.
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