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To exclude that the two different EGFP cortactin constructs used did not display erroneous behaviour perhaps due to being non-functional, we tested a third, independently generated EGFP cortactin, the functionality of which had previously been confirmed by reconstitution of a knockdown phenotype (Zhu et al, 2007).
For this we used lysozyme adsorbed to mica, the functionality of which was characterized by enzyme immunoassays.
Apart from an alpha-beta hydrolase motif, the functionality of which remains questionable [45], NDRG1 has no known protein motifs that would impart it a function.
But the LCT locus, the functionality of which is responsible for lactase persistence, has been under positive selection in the European population [ 41].
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Disrupting the lipid rafts' integrity, which are plasma membrane microdomains rich in cholesterol, may modify tumorigenic processes by altering the functionality of CD44, which is a cell surface receptor involved in cell migration and tumor metastasis [ 150, 151].
Designing an additional channel in the northern part of the models, directly impacts the functionality of DSF, which can be concluded to be very efficient.
We also discuss some of the key strategies to enhance the functionality of MSCs, which include sorting and/or priming with factors such as cytokines, as well as genetic engineering.
While the serine residue left after cleavage of the more efficient furS site prevented GrB activity, it did not interfere with the functionality of GST, which like many other enzymes does not require exact N-terminal trimming to yield the enzymatic activity of the wildtype protein.
This is the reason why PathText needed to integrate the functionality of FACTA, which is tuned for real-time uses with a special index structure.
Table 3 contains a comprehensive description of all the SNVs located in the seed regions, putatively critical for the functionality of miRNA, which occurs by complementarity with their respective targets.
The key component in a meshed network architecture is the optical cross-connect (OXC), the basic functionality of which is to switch a signal from an in-going port to the appropriate outgoing port.
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