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This suggested that, despite the fact that the salmon elongases appear to be subjected to functional constraints in order to maintain the functionality of the protein, the nucleotide sequence of one of the duplicates seems to be diverging faster than the other.
Coiled coil motifs are associated with different functions in proteins and thus may be very important to understand the functionality of the protein [19].
The HemosIL ThromboPath assay (Instrumentation Laboratory) is a new chromogenic assay designed to globally evaluate the functionality of the protein C (PC) pathway.
The ProC® Global is a clotting assay designed to globally evaluate the functionality of the protein C (PC) pathway, which is found defective in up to 30% of the Caucasian patients with thrombophilia.
This would more likely guarantee the functionality of the protein as a whole than replacement by a dissimilar amino acid.
The α chain haptoglobin polymorphism influences circulating haptoglobin concentrations to a lesser degree compared with its impact on the functionality of the protein [14].
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The process of multimerization, aside from being related to the functionality of the proteins, may also affect the dynamics of the processes that the proteins regulate.
Our previous similar kind of computational analysis shows that the N-glycosylation sites and O-glycosylation sites are vital for the functionality of the proteins in the insulin signalling pathway proteins such as IRS and GLUT4 [ 67, 92].
However, the modified proteins EF-G-Y339A/D and EF-TU-Y270D perturbed vegetative growth (Additional file 16: Figure S9B and S9D), signifying the importance of these sites for the functionality of the proteins.
It is observed that within protein families, only limited flexibility is allowed in such local conserved regions, while large irregular gaps may be present in between these regions as long as the inserted or deleted segments do not affect the functionality of the proteins [ 3, 12- 14].
Correct incorporation of the Fe-S cluster into SDH is a prerequisite for the functionality of the SDH protein, and downregulation of proteins involved in Fe-S cluster biogenesis could lead to diminished SDH activity.
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