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We propose a novel algorithm called FACETS that discovers an atlas of functionally unique decompositions from a PPI network, portraying alternative views of the functional landscape of the network (detailed in Section 2).
Zhang, W. et al. The functional landscape of mouse gene expression.
Overall, interpreting experimental results in the light of the functional landscape paradigm considerably enhances the understanding of complex biomolecular processes.
On the other hand, because the functional landscape topographies are complicated, the native state dynamics are often difficult to interpret.
CRISPR saturation mutagenesis has the potential to dissect the functional landscape of noncoding regions, but is highly susceptible to false discovery and misinterpretation.
Starting with baculovirus-expressed fruit fly tRNase Z, we completed an 18 residue Ala scan of the His cluster to analyze the functional landscape of this critical region.
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We carried out the comparative analyses of the functional landscapes of the AS using the consensus assembly of expressed sequence tags and available mRNA sequences in four cereal plants.
Three scenarios developed for the aggregation of multiple considerations are demonstrated with maps — based on the status quo of the "(mono -functional landscape", the "mono -functional landscape" and the "sustainable landscape".
The distinct functional landscape of the mitochondrial genome likely affects the distribution of selective effects (s) of mutations that arise in this genome.
The dynamic functional landscape of the hepatic transcriptional adaptation to excess dietary fat during the 16-week time-course suggests a model in which sequential physiological changes underlie the transition from metabolic stress to metabolic syndrome, summarized in Figure 9.
Most importantly, the overall functional "landscape" fits with the known role of estrogen hormones as activators of cell proliferation [34].
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CEO of Professional Science Editing for Scientists @ prosciediting.com