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The functional influences of CnSNPs were studied using bioinformatics software, including Polyphen (27) and SIFT (28).
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To determine the functional influence of the His547 (H547A) mutation in DAT function, kinetic analysis of [3H]DA uptake was performed in PC12 cells transfected with WT hDAT or H547A-hDAT.
We also evaluated the functional influence of other substitutions of Histidine547 (His547) and its associated residues, tyrosine548 and tyrosine551, in DA transport as well as Tat-induced inhibition of DA uptake.
At three sites along an elevational gradient in eastern U.S. temperate forest, we used a reciprocal litter transplant design to explore whether climate masks the functional influence of the decomposer community on litter decomposition dynamics in the short- and longer-term.
In principle, one should also evaluate the functional influence because different density functionals treat electron correlation differently yielding different results here.
The present study investigates the functional influence of BA 5 on the neural circuitry within M1.
The functional influence of these polymorphisms within our candidate genes will require substantial in vivo and in vitro investigations.
Next, we analysed the functional influence of CTGF in malignant melanoma.
To clarify the functional influence of the CAR– α-catenin interaction, we performed in vitro assays after CAR knockdown and the ectopic 're'-expression of α-catenin.
To investigate the functional influence of the PlxnD1/Sema3E pathway on dermal MVEC in vitro angiogenesis, we performed capillary morphogenesis on Matrigel matrix.
To gain further insight into the possible molecular basis of the association, we examined the functional influence in vitro of associated polymorphisms in the regulatory region of TF.
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