This suggests that the functional impairment caused by the nes2 and nes7 amino acid substitutions was unaltered when a functional NES is added to the C-terminus, whereas the functional impairment caused by the triple alanine substitutions is partially alleviated by the C-terminal addition.
Insufficient autophagy also impairs myofiber homeostasis, leading to accumulation of damaged or dysfunctional cell components, with structural and functional impairment causing muscle weakness.
With the severe functional impairment caused by the rare coding variants in these individuals (BMI 39.0 ± 7.6 kg/m in adulthood, 32.7 ± 8.0 kg/m in childhood) (Thearle et al. 2012), the additional influence of any, presumably more moderate, functional effects of common variants is likely negligible.
This approach seeks to improve on traditional risk assessment practices by looking beyond the structural penetration of the satellite and predicting the physical damage to internal components and the associated functional impairment caused by untrackable debris impacts.
Limited walking ability is the dominant functional impairment caused by LSS.
The clinical presentation of canine visceral leishmaniasis vary widely depending both on the organ(s) affected and the extent of functional impairment caused by the infection, and therefore, diagnosis may become a real challenge, particularly if the animal do not live in an endemic area or, alternatively, if the disease appears in an unusual clinical form [ 3].
The progression of cognitive and functional impairment caused by AD pathobiology is insidious; defining a discrete disease onset seems arbitrary.
The first 13 questions concern periods of life-time symptoms of mania and hypomania, and the last two ask about co-occurrence of symptoms and ranking of functional impairment caused by the symptoms.
Despite the high prevalence and incidence of TTH, scientific interest in TTH has long been sparse probably because the pain intensity, associated symptoms and functional impairment caused by TTH are relatively mild compared with those caused by migraine.
p38MAPK activity increased upon reperfusion and p38MAPK inhibition by the inhibitor BIRB796 almost completely prevented severe functional impairment caused by IR.
However, in contrast to studies with the FOLFOX-6 regimen, where 21% of patients reported functional impairment caused by sensory neuropathy with a median administered oxaliplatin dose of 900 mg m−2 (Louvet et al, 2002a), the intensity of neuropathy observed in our trial, where the median dose of oxaliplatin was 800 mg m−2, did not exceed mild to moderate grades.
