We determined the functional effect of combined MET EGFR inhibition on the cytoskeletal functions of H1975 cells.
Predicting the functional effect of amino acid substitutions and indels.
PROVEAN web server: a tool to predict the functional effect of amino acid substitutions and indels.
Choi, Y. & Chan, A. P. PROVEAN web server: a tool to predict the functional effect of amino acid substitutions and indels.
Choi, Y., Sims, G. E., Murphy, S., Miller, J. R. & Chan, A. P. Predicting the functional effect of amino acid substitutions and indels.
The functional effect of this region remains to be clarified in the future studies.
The functional effect of the NS1 mutation on viral replication and possibly neurovirulence in mice as well as mosquito infection supports its role in enhancing the recent epidemics and pathogenic potential of ZIKV.
Fujita, K. et al. Membrane topography of the hydrophobic anchor sequence of poliovirus 3A and 3AB proteins and the functional effect of 3A/3AB membrane association upon RNA replication.
To determine the functional effect of HK2 on regulating glucose metabolism directly, we created stable HK2 knockdown SW480 cells using two different shRNA targeting sequences, and knockdown of HK2 had no effect on HK1 expression (Figure 6a).
Neither the mean level nor the laminar distribution of COMT mRNA was related to the Val108/158 Met genotype, suggesting that the feedback regulation of mRNA level is not a compensation for the functional effect of the COMT polymorphism.
Modeling the functional effect of a mutation is, however, a nontrivial task, due to strong functional interdependencies.
