Sentence examples for the functional centrality from inspiring English sources

Despite the functional centrality of these transitions in multicellular organisms, it has remained challenging to determine which transitions occur and at what rates without perturbations and cell engineering.

The functional centrality of this node extends across the entire plant kingdom.

Thus, the functional centrality of Housekeeping genes determined the network topological centrality of these genes, performing the crucial functions with the high degrees.

However, because of the functional centrality of these targets and their large impact on protein network architecture and robustness we can anticipate that drug designed on this rational could generate molecules with high toxicity.

Correspondingly, this concept provides a characterization of the robustness and functional centrality for each enzyme involved in a given metabolic network.

We argue that functional centrality, namely the extent to which a functional department is central in the intra-organizational network, affects employees' innovation intensity.

There is a significant negative correlation of EVs of RS and RS2 proteins and their number of protein interactions, which supports our hypothesis that differential expressional variation of genes within the signaling hierarchy can at least in part be explained by their functional centrality in the signaling network.

Since high connectivity means high functional centrality in the gene network, they proposed that mouse duplicates probably are more important than singletons and that this factor could compromise the contribution of duplicate compensation.

Our analysis shows that this pattern of EV reflects functional centrality: proteins with highly specific signaling functions are modulated more frequently than those with highly central functions in the network, which is also consistent with previous studies on tissue-specific gene expression.

If this view is correct, then phenotypic potential is not so much a measure of direct buffering, but rather of functional importance and of functional centrality in cellular networks.

Therefore, the cancer gene set also had the functional and topological centrality in complex biological networks and played the critical role in the development of diseases.