Sentence examples for the functional affects from inspiring English sources

Further, to facilitate identification of how novel immunomodulatory treatments alter the functional affects of microglia, we characterised how the soluble products from polarised microglia affected the type and rate of neuronal death; M1/2b induced increasing and M2a-induced decreasing neuronal loss.

In support of this hypothesis, previous studies have shown that disrupting GRK2 activity through over-expression of a dominant-negative mutant lacking kinase activity significantly reduced MOR endocytosis promoted by DAMGO [46] or etorphine [39] and consequently the functional affect of opioid drugs at the MOR [47].

Mice transgenic for ASPM, and in vitro assays for MCPH1 confirm changes in the coding sequence have functional affects [ 25, 84].

This resembles the functional groups affected by early gene expression changes and supports the conclusion that transcriptional and epigenetic regulation may affect the establishment of senescence at the level of gene expression (manuscript 000141R1 in AGING).

Molecular changes were mapped in 23 striatal sectors mostly defined by their predominant cortical inputs in order to determine the functional domains affected.

It was analysed how the number of the polyoxyethylene repeating units or the exchange of the functional groups affect the dispersion mechanisms of multiwalled carbon nanotubes (MWCNT) namely Nanocyl™ NC7000 in LLDPE.

Table 1, adapted from Davidse [31], shows a summary of the functional decline affecting elderly drivers and the assistance needed to overcome this functional decline.

We addressed the methodological challenges of the identification of the functional entities affected by GWAS-detected variants.

In line with that observation the functional categories affected by the transcriptional changes were very distinct across tissues [ 15].

Although the overlap in the transcripts is not so high the overlap of the functional categories affected by each mutant is more significant.

This tier involves ranking overlapping pieces of the molecular landscape by value of the functional protein affected by that molecular event in the disease process.