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Importantly, full exploitation of the potential of hESCs will require the complete understanding of the function of the genetic factors that specify stem cell identity and regulate their commitment towards specific differentiated cell lineages.
Therefore, the function of the genetic polymorphism implicated (rs4072037 G/A, located at nucleotide position 8 of exon 2 of the b variant) was left in some doubt.
This is particularly fit when considering genomes from the algorithmic point of view that underlies the function of the genetic program.
In these cases, a gene of interest is selected and targeted by morpholino oligonucleotide (MO) knockdown, TILLING (Targeting Induced Local Lesions IN Genomes), or zinc-finger nucleases to discover the function of the genetic mutation within the fish [ 9- 14].
The specific association of a genetic variant with a single risk factor may be a reasonable assumption if the function of the genetic region where the variant is located is well-characterized.
If the function of the genetic variants is poorly understood, and there is little consistency in the causal effect estimates from multiple variants, then a causal conclusion is in doubt.
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Therefore, a major challenge to all biologists is how to efficiently translate the functions of the genetic code sequences.
Furthermore, other genetic polymorphisms that modulate the function of the reported genetic markers also may vary among racial populations, rendering them inconsequential in nontested ethnic populations.
This is in line with the fact that genetic variants near IRS1 were associated with multiple features of the MetS (14– 17, 21), though the function of these genetic variants has not been clarified.
Analysis of the function of the lupus-associated genetic variants should provide important insights into pathogenic mechanisms that can be applied to development of highly targeted therapeutics.
The function of the nucleus as carrier of genetic information became clear only later, after mitosis was discovered and the Mendelian rules were rediscovered at the beginning of the 20th century; the chromosome theory of heredity was therefore developed.
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