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The sensitivity of PCR is dependent on the function of the DNA's cycle, amount and integrity.
However, it is hard to pre-define the range required for comparison in a large case-control dataset, since the range is closely related to the function of the DNA segment.
ACF may modulate the function of the DNA binding proteins throughout different stages of the parasite life cycle.
Arsenic may also work by an epigenetic mechanism that changes the function of the DNA without affecting the normal DNA sequence.
Our results demonstrate that deletion of mrc1 sharpens the replication profile not because it impairs the function of the DNA replication checkpoint, but because it impairs the normal progression of the replication fork.
Moreover, in 2001 an important adjustment was made to patent regulations in the US, which stated that patent applications for DNA sequences had to explain the function of the DNA sequence that was to be patented (USPTO).
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Linker length and sequence are important for the function of the DNA-binding C2H2 ZF, because they determine the distance of each ZF and the linker contacts to the DNA base [ 60- 62].
Based on knock-downs of CTC1 and OBFC1, it appears that the complex is not only involved in telomere maintenance, perhaps by negatively regulating telomerase (30, 32), but is also engaged in the functioning of the DNA replicative fork, which is not strictly related to telomere protection (29, 33).
This modification changes the function of the methylated DNA dramatically.
There are different trends of TE frequencies, presumably suggesting different slope-specifc adaptations due to natural selection on the function of the regulated DNA.
However, future studies should sequence the PCR products to predict the function of the identified DNA sequences and to assist in explaining the levels of polymorphism reported between the susceptible and resistant snails.
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