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The most straightforward approach of computational functional annotation is to infer the function of a gene based on the functions of genes returned by a database search for similar genes.
Several studies have shown that a functional interaction network provides information about the function of a gene of interest using the guilt by association concept [ 44, 45].
Gene expression pattern data has been used in the past to uncover the function of a gene.
One or more functions have been determined for many human genes, and additional interest lies in characterizing functional domains and assessing the effects of truncation and point mutations on the function of a gene product.
It is caused by mutations that destroy the function of a gene that is needed to make T cells, a class of white blood cells.
In other words, the function of a gene can often be discovered by silencing it.
Yet the cost of identifying the function of a gene is a fraction of the cost of turning that gene into something useful, like a drug.
Silencing the function of a gene in this way sometimes can allow a researcher to infer what the function of that gene may be.
Gene silencing or RNAi has opened new potential opportunities to study the function of a gene in an organism.
In order to determine the function of a gene, various domains can be identified that are common to proteins of similar function.
A report launched today by scientists at the Medical Research Council (MRC) and London School of Hygiene and Tropical Medicine found that a mother's nutritional status at the time of conception can permanently change the function of a gene that influences her child's immunity and cancer risks.
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