In the second network, this function is fulfilled by the nucleus accumbens and caudateputamen, receiving extensive input from sensory, motor and associational cortical areas; a third analogue would by a hybrid of these two networks consisting of premotor/motor cortico-basal ganglia loops.
Lactate that is produced from hypoxia-induced or oncogene-driven LDHA expression also needs to be removed to avoid acidification of the intracellular compartment: this function is fulfilled by dedicated transporters called MCTs (see below).
Today this function is fulfilled by the local primate who is sometimes called patriarch (in the autocephalous churches of Constantinople [Istanbul], Alexandria, Antioch, Jerusalem, Russia, Georgia, Serbia, Romania, Bulgaria, and Ukraine), but he may also carry the title of archbishop (in Cyprus and Greece) or metropolitan (in Poland, the Czech Republic, Slovakia, and the United States).
Today this function is fulfilled by the local primate who is sometimes called patriarch (in the autocephalous churches of Constantinople [Istanbul], Alexandria, Antioch, Jerusalem, Russia, Georgia, Serbia, Romania, and Bulgaria), but he may also carry the title of archbishop (Cyprus, Greece) or metropolitan (Poland, the Czech and Slovak republics, the United States).
In yeast, this function is fulfilled by the superfamily 1 (SF1) helicase Rrm3, a 5′ 3′ helicase required for efficient replication at numerous protein-bound sequences such as in rRNA and tRNA genes, centromeric and telomeric regions (Azvolinsky et al, 2006; reviewed in Boule and Zakian, 2006).
In Drosophila, the PRC2 catalytic subunit is the single protein E z), while in mammals this function is fulfilled by two proteins, Ezh1 and Ezh2.
In other yeast species and filamentous fungi, this function is fulfilled by Pex20 (Einwachter et al. 2001).
The cognitive function is fulfilled characteristically by 3rd-person nonmodal utterances (i.e., utterances in the indicative mood, making no use of modal verbs); the expressive function by 1st-person utterances in the subjunctive or optative mood; and the conative function by 2nd-person utterances in the imperative.
According to the definition proposed by Koonin et al. [ 26], an event of non-orthologous gene displacement can be suspected when the same function is fulfilled by unrelated or distantly related proteins.
We reasoned, however, that if ALT function is fulfilled within the host rather than within the parasite, we can validly study these proteins by transgenic expression in a more tractable carrier species.
This function is fulfilled by the Large T antigen in SV40 (5).
