The full range of potential contributing factors is presented.
Figure 3, a conceptual map rather than a depiction of empirical processes, highlights the importance of identifying the full range of effectors potentially at play.
We believe this is a valuable conceptual framework for thinking about rare illnesses since it highlights the full range of factors potentially influencing speed to diagnosis, rather than the presenting features of the illness alone.
"Some physician groups are steering patients to the most lucrative treatment they offer, depriving patients of the full range of treatment choices, including potentially no treatment at all," said Dr. Steinberg, who is the chairman of radiation oncology at the U.C.L.A. medical school.
Such variation makes it difficult to design a vaccine that covers the full range of diversity, and could potentially facilitate the evolution of vaccine-resistant parasite strains.
Because of this, estimation of a single hazard ratio (HR) across the full range of BMI values is potentially misleading.
Although the random effects model does better justice to the full range of data available, it does potentially allow a larger weight to be given to smaller studies that may have been selected for publication on the basis of their higher event rates [ 18].
First, a lack of objective evidence on effectiveness for the full range of intervention options (existing and potential) across settings, sub-populations and the care continuum may leave a potentially large number of interventions excluded from explicit performance measurement.
Experimental approaches are direct but typically time-consuming, expensive, potentially subject to artefact, and do not project the full range of biological complexity [ 1], whereas computational methods are potentially faster and more-general, may be less-accurate [ 2], and ultimately require empirical validation.
The full range of epigenetic marks is currently unknown but is potentially enormous, considering that the diploid human epigenome contains >10 Cytosines (of which >10 are CpGs) and >10 histone tails that can all potentially vary.
