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Thes combined results and the frequent expression of these antigens on melanoma cells from different patients suggest that assays to detect this antigen may provide a valuable immunodiagnostic aid in the management of melanoma.
The frequent expression of neurotensin receptors (NT-R) in primaries of pancreatic ductal carcinomas has triggered the development of radioactive neurotensin analogs for possible in vivo targeting of these tumors.
The frequent expression of pErk5 in breast tumours merits some comments.
This is notable due to the frequent expression of CT genes in melanomas; e.g., MAGEA1 (reviewed in [27]).
The frequent expression of EGFRvIII in human cancers but not in normal tissues makes it a promising target for therapeutic applications.
We also evaluated a panel of PDA tumor cell lines and 52 fresh tissue specimens and showed the frequent expression of cell surface ANXA2 in primary PDAs, which further supports a role for ANXA2 in PDA progression.
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On the contrary, frequent expression of the MK gene implies a possible strategy of MK promoter-based therapy for HCC patients, although the expression is not specific to HCC.
MM is probably the cancer with the most frequent expression of cancer-testis antigens (CTA), a class of tumor antigens characterized by its tumor-restricted expression and high immunogenicity.
Over the previous year, the most frequent expression of violence was verbal, followed by yelling and heavy pranks, unarmed physical aggression and, representing the lowest proportion, fraud or deception.
The most frequent expression profile (42.8% of the strains) comprised seg, seh, sei, eta, etb, and hla.
Due to the restricted expression pattern, combined with the wide expression in tumors, NY-BR-1 seems to be an ideal potential target for innovative immunotherapeutic approaches of breast cancer because of the more frequent expression in comparison to HER2/neu, the current reference target for cancer immunotherapy.
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