Because the foundational methods developed here are structure based, these results suggest that the approach can be more generally applied to specificity prediction and redesign of other protein protein interfaces that have structural information but lack phage display data.
Considering systems in their entirety strikes me as the only possible foundational method for identifying those levers capable of transformative change, of which Acumen's many successful portfolio companies serve as a testament.
Many approaches have been used in the literature for robust clustering, and the k-means algorithm (MacQueen 1967) can be considered as one of the most foundational methods.
This paper explores the use of a cyber-physical systems (CPS) approach to optimize the design of rigid, low-rise structures subjected to wind loading, with the intent of producing a foundational method to study more complex structures through future research.
To this end, sitting meditation called "za-zen" is employed as a foundational method of prāxis across the different schools of this Buddha-Way, through which the Zen practitioner attempts to embody non-discriminatory wisdom vis-à-vis the meditational experience known as "satori" (enlightenment).
The present study conducted a comparative analysis of the most frequently used target prediction algorithms and developed an integrative approach, with certain analytically attractive properties, that improves the predictive performance in relation to the foundational prediction methods.
It's stifled me since high school, and while I've consistently chipped away, I've struggled to find foundational methods that can help me break through.
The foundational concepts and methods of computational protein engineering are discussed, and an example of a computational modeling and structure-guided protein engineering workflow is provided for the design of best-in-class heterodimeric Fc with high purity and favorable biophysical properties.
Adopting weighted margin method, the foundational control equations for calculating the temperature field are derived, and two types of thermal boundary conditions are tackled.
The iTools design and Java-implementation include a small resource core that contains the foundational database and interface objects and methods.
