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Despite the relevance of both pathways in the pathogenesis of the disease, and the fact that this is indeed the first study that considers these pathways as a candidate-gene selection approach, our study does not present any evidence of the presence of low-penetrance variants for the selected markers in any of the considered genes in our cohort.
Indeed, the first study that comprehensively assessed plasma concentrations of APC proteins in AMD patients and controls found higher levels of activation products in the AMD cohort [ 41].
In Cambodia, this is the first study of OD productivity, and indeed it adds to a very limited body of evidence on health district efficiency (most studies which have been done in low and middle income settings have analysed the hospital as the unit of production), and on the impact of health sector reforms on productivity.
Indeed, this is the first study to demonstrate that baseline cartilage defects predicted site-specific BML progression.
Indeed, ours is the first study to evaluate the association between SES and outcome of arthroplasty in the Australian public health care system.
Indeed, this is the first study involving the role of antiviral prevention in breast cancer patients receiving anthracycline-based adjuvant chemotherapy.
Indeed, this is the first study to examine the secondary prevention of low back pain in a large population of health care institution personnel in France.
To our knowledge, this is the first study to use such an approach and indeed to identify different effects of anti-TNFα treatment in normal-weight vs. obese individuals with RA.
Indeed, they claim it to be the first study of its kind.
Indeed, insertion times decreased from 24 min in the first study of the device (8) to 15 min in this study.
Indeed, patients were recruited between 04/2004 and 03/2005 for the first study and between 07/2007 and 09/2009 for the second study.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com