Exact(2)
In the first spindle (numbered 12 in Winey et al). the two pole-to-pole microtubules are assigned symmetrically to each SPB.
The first spindle sets up centrally but is pulled toward the posterior, culminating in an asymmetric first cell division with a larger anterior cell, AB, and a smaller posterior cell, P1. csnk-1 RNAi) csnk-1 RNAiw cortical dembryosand abnormalitieshow pronucorticaldefectsle positioning.
Similar(58)
The second spindle (numbered 14 in Winey et al).
The transient microtubule array compacts and evolves to the first meiotic spindle (MI spindle).
Finally, the two centrosomes, one derived from the GC, and the other derived from the PCL, migrate to the spindle poles of the embryo's first spindle.
After the male and female pronuclei have come into contact, the spermatozoal centrioles give rise to the first cleavage spindle, which precedes division of the fertilized egg.
Brunet, S. et al. Kinetochore fibers are not involved in the formation of the first meiotic spindle in mouse oocytes, but control the exit from the first meiotic M phase.
However, this gradient is dispensable for assembly of the first meiotic spindle.
It is interesting to note that the K-fibers are not involved in the formation of the first meiotic spindle or meiotic chromosome congression to the metaphase plate [27].
This delay leads to a failure of paternal chromosomes, particularly the heterochromatin-rich sex chromosomes, to separate on the first mitotic spindle.
The spindle is crucial for the events following fertilization in the completion of meiosis, second polar body formation, migration of the pronuclei, and formation of the first mitotic spindle.
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