Sentence examples for the first ever administration from inspiring English sources

In contrast, the first ever administration of L-DOPA to MPTP-lesioned monkeys induced a trend toward increased phosphorylation of DARPP-32 at Thr34, and a significant increase in phosphorylation of GluR1 at Ser845 (Fig. 2A B).

In contrast, after dopamine denervation, the first ever administration of L-DOPA activates both signalling cascades, as evidenced by the significant increases in the levels of phospho-Ser845 GluR1 phospho-Ser845 GluR104-ERK and phospho-Thr202/Tyr204-ERK(Fig. 2).

At odds with this classic view, the present data suggests that the DA-depleted striatum is so sensitive to a de novo acute L-dopa treatment that the first ever administration alone is able to induce rapid PTM-based proteomic changes that do not seem to be modified by chronic L-dopa treatment.

The common denominator for these profiles is the clear effect of L-dopa in acutely treated animals, i.e. of its first ever administration.

Australia's leading scientific expert on the endangered Leadbeater's possum has publicly lambasted the Victorian state government, claiming it is the first ever domestic administration to take "calculated actions" that it knew could wipe out a threatened species.

The LDP's worst electoral defeat in history opens the door for the first ever DPJ administration, a party that has pledged to spend as much $170 billion in targeted benefits, with money it says will come from redirecting spending away from bureaucrat-controlled projects.

Significantly, this is the first ever report of administration of a plant-made VLP vaccine to humans.

Portsmouth were the first ever Premier League club to enter administration in February 2010, and despite a host of high-profile signings and reaching an FA Cup final, fell from the top-flight into the Championship last year.

We next examined whether changes in phosphorylation of ERK1/2 were associated with the first ever and/or the chronic L-DOPA administration.

In 2011, the Obama administration rolled out the first ever fuel-efficiency rules for Class 8 trucks, the heaviest vehicles on the road.

The Trump administration has approved the first ever U.S. commercial sale of lethal defensive weapons to Ukraine, in a clear break from the de facto U.S. ban on arms sales that dates back to the Obama administration.