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The first difficulty of such a type of problem is the lack of the compactness of the Sobolev embedding.
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Time management was one of the first difficulties for clinic physicians.
The first difficulty is the measurement of rotational degrees of freedom.
The first difficulty is the production of sufficient quantities of authentic DNA sequences to make a study conclusive.
The first difficulty is the lack of common frameworks for thorough comparisons of toponym disambiguation.
The first difficulty is the construction of customized genetic operators to perform the mating process on the chromosomes.
The first difficulty arises with the design of the TEF.
The first difficulty is that the number of HFA spectrograms is too large for a manual trace of UHR emissions in the spectrogram.
The first difficulty arises by motivating a flux of spin in a non-polar medium.
The first difficulty lies in the exact characterization of the breakpoints.
In fact, this approach is one of the causes of the second difficulty since thousands of molecular descriptors are currently extant [13, 14].
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