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One of the first difficulties in developing monoclonal antibody therapeutics was the recognition that human anti-mouse antibody (HAMA) response limited the administration of murine antibodies.
Time management was one of the first difficulties for clinic physicians.
One of the first difficulties to overcome was the limited amount of cffDNA in the maternal circulation (3 to 6% [ 15] or 10 to 20% based on recent studies [ 16]).
When you decide to quit drinking forever, one of the first difficulties you will face is simply dealing with the day-to-day reality without alcohol.
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The first difficulty is the space.
The first difficulty arises with the design of the TEF.
DR. SOWWAN says the first difficulty was fund-raising.
The Turkish bureaucracy was the first difficulty that Beyoglu AS faced.
The first difficulty is, how do you transfer the old debts?
The first difficulty with this number is that many people simply don't believe it.
The first difficulty is in deciding the appropriate unit for measuring resources.
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CEO of Professional Science Editing for Scientists @ prosciediting.com